A New Strategy for Cancer Chemotherapy
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چکیده
The manuscript, in which the CNIO Groups of Dr. Mariano Barbacid and Dr. Manuel Hidalgo, as well as the Group of Dr. Bruno Amati at the Italian FIRC Institute of Molecular Oncology (IFOM) have participated, describes a new strategy that allows a selective killing of cancer cells, given that the tumours present a particular feature. One of the main limitations of current cancer therapy is that the treatment usually is not only toxic for the tumour, but also for the healthy tissue. This is the source of the widely known off-target effects of radioand chemotherapy; which may significantly affect the patients ́ health. In this context, many of the current efforts are dedicated to the discovery of chemicals that are particularly toxic for cells harbouring cancer-associated mutations. Besides the presence of mutations, another approach is whether the therapy could exploit a more generic feature of cancer cells.
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